摘要 :
Nanomedicine-enabled/augmented ultrasound (US) medicine is a unique area of interdisciplinary research that focuses on designing and engineering functional nanosystems to address the challenging issues in US-based biomedicine, ove...
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Nanomedicine-enabled/augmented ultrasound (US) medicine is a unique area of interdisciplinary research that focuses on designing and engineering functional nanosystems to address the challenging issues in US-based biomedicine, overcoming the shortcomings of traditional microbubbles and optimizing the design of contrast and sonosensitive agents. The single-faceted summary of available US-related therapies is still a significant drawback. Here, The proposal of a comprehensive review on the recent advances of sonosensitive nanomaterials in advancing four US-related biological applications and disease theranostics is aimed. In addition to the mostly explored nanomedicine-enabled/augmented sonodynamic therapy (SDT), the summary and discussion of other sono-therapies and progresses/achievements are relatively lacking, including sonomechanical therapy (SMT), sonopiezoelectric therapy (SPT), and sonothermal therapy (STT). The design concepts of the specific sono-therapies based on nanomedicines are initially introduced. Furthermore, the representative paradigms for nanomedicine-enabled/enhanced US therapies are elaborated according to therapeutic principles and diversity. This review provides an updated and comprehensive review of the field of nanoultrasonic biomedicine, and comprehensively discusses the progress of versatile ultrasonic disease treatments. Finally, the deep discussion on the facing challenges and prospects is expected to promote the emergence and establishment of a new branch of US biomedicine through the rational combination of nanomedicine and US clinical biomedicine.
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摘要 :
Immunotherapy has become one of the most effective therapeutic modalities
for achieving long-term cancer remission, but the available
immunotherapeutic strategies suffer from modest response rates owing to
the insufficient immu...
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Immunotherapy has become one of the most effective therapeutic modalities
for achieving long-term cancer remission, but the available
immunotherapeutic strategies suffer from modest response rates owing to
the insufficient immunogenicity of tumor cells. In this work, a nanomedicine
strategy for maintaining highly immunogenic tumor cells by inducing
cascade-mediated immunogenic tumor-cell ferroptosis is proposed and
developed. A PdMoP nanoplatform is engineered that not only induces initial
immunogenic tumor cell ferroptosis through its multienzyme-mimicking
activities but also accelerates Mo(Ⅳ)-to-Mo(Ⅵ) transition, which aggravates
glutathione (GSH) depletion for deactivating glutathione peroxidase 4 (GPX4)
enzyme and lead to excessive radical production for promoting p53
expression and reducing SLC7A11, thereby resulting in efficient ferroptosis
and apoptosis. Additionally, PdMoP nanoparticles induce the breakdown of
hydrogen peroxide into oxygen to alleviate tumor hypoxia, working
synergistically with GSH depletion to reverse the immunosuppressive tumor
microenvironment. Significant ferroptosis (through the classical
p53-SLC7A11-GPX4 pathway) is monitored in both in vitro cellular level and in
vivo tumor models, achieving effective tumor suppression and elimination.
The distinct ultrasound-enhanced enzyodynamic therapy strategy represents a
simple and effective paradigm for treating cancer by nanocatalytic medicine
and catalytic biomaterials.
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摘要 :
Sonodynamic therapy demonstrates tremendous potential in biomedicine
due to its non-invasiveness, deep tissue penetration, and spatiotemporal
controllability. However, the lack of favorable nanosonosensitizers with
prominent re...
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Sonodynamic therapy demonstrates tremendous potential in biomedicine
due to its non-invasiveness, deep tissue penetration, and spatiotemporal
controllability. However, the lack of favorable nanosonosensitizers with
prominent reactive oxygen species generation capability and green chemical
constituents remains a significant challenge for its broad biomedical applications.
Herein, a homologous bismuth-based nanosonosensitizer (Bi-HJ) is
designed and fabricated by direct defect engineering for combinational tumor
therapy. Specifically, self-derived Schottky heterojunction and oxygen vacancies
are concurrently constructed in Bi-HJ, which prominently promotes the
separation of ultrasound-triggered electron–hole pairs and improves the
charge utilization efficiency. With the porous structure, Bi-HJ is loaded with
a metabolic regulation drug atovaquone to block the mitochondrial respiration
for oxygen-economized sonodynamic tumor suppression. The strong
near-infrared absorption of Bi-HJ imparted by oxygen vacancies allows
the implementation of photothermal therapy. Accordingly, Bi-HJ rationally
combines two therapeutic modalities and metabolic regulation function, as
well as computed tomography imaging ability, thus achieving effective tumor
theranostics in vitro and in vivo. Therefore, this study provides new insight
into the fabrication of homologous nanosonosensitizers without the introduction
of other constituents for synergistically enhanced tumor therapy.
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摘要 :
Piezocatalytic tumor therapy is an emerging reactive oxygen
species (ROS)-generating therapeutic approach that relies on piezoelectric
polarization under ultrasound (US) irradiation. Optimizing ROS production
is a primary objec...
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Piezocatalytic tumor therapy is an emerging reactive oxygen
species (ROS)-generating therapeutic approach that relies on piezoelectric
polarization under ultrasound (US) irradiation. Optimizing ROS production
is a primary objective for enhancing treatment efficiency. In this study,
oxygen-vacancy-rich Pd-integrated black barium titanate (BTO) nanoparticles
are rationally engineered to boost the ROS generation efficiency via the
introduction of Pd. Pd-catalyzed hydrogenation at low temperatures narrows
the bandgap of BTO and reduces the recombination rate of electron-hole
pairs. Furthermore, Pd has dual-enzyme-mimicking characteristics, including
peroxidase- and catalase-mimicking activities, which further heighten
the therapeutic efficacy by enhancing ROS production and reversing the
hypoxic tumor microenvironment. Importantly, the dual enzymatic activity of
Pd can be amplified by multiple redox processes sparked by the piezoelectric
potential under US stimulation, resulting in bilaterally enhanced multienzymepiezoelectric
synergetic therapy. In vitro and in vivo results confirm
high tumor inhibition in murine breast cancer cells. This work stresses the
critical effects of defect engineering-optimized piezodynamic tumor therapy.
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摘要 :
The anticancer mechanism of nanozymes is dominantly associated with
the capacity for generation of reactive oxygen species (ROS) caused by the
valence change of metal elements. However, very little research is focused
on and ha...
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The anticancer mechanism of nanozymes is dominantly associated with
the capacity for generation of reactive oxygen species (ROS) caused by the
valence change of metal elements. However, very little research is focused
on and has achieved the exploration and development of enzyme-mimicking
activities of valence-invariable metal compounds. Herein, a distinct valenceinvariable
calcium fluoride (CaF_2) nanozyme with ultrasound (US)-enhanced
peroxidase (POD)-mimicking activity is rationally designed and engineered
for efficient calcium (Ca~(2+))-overload-enhanced catalytic tumor nanotherapy,
which is the first paradigm of Ca-based nanozymes for catalytic cancer treatment.
The release of exogenous Ca~(2+) ions from CaF_2 nanocrystals and deleterious
ROS generation derived from US-amplified POD-mimicking properties
facilitate intracellular Ca~(2+) accumulation and achieve Ca~(2+)-overload-induced
mitochondrial dysfunction through introducing exogenous Ca~(2+) ions and
regulating calcium-pumping channels of neoplastic cells. Especially, US as
an exogenous energy input is capable of substantially amplifying POD-mimicking
catalytic activities of CaF_2 nanozyme, ultimately achieving efficient antineoplastic
outcome on both 4T1 breast tumor and H22 hepatic carcinoma
animal models. Such a discovery of enzyme-like activity of valence-invariable
metal compounds can broaden the cognition scope of nanozymes and effectively
serves the field of catalytic and chemoreactive nanomedicine.
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摘要 :
The delivery of nano-zerovalent iron (nZVI) as a remediation agent to targeted areas in soil was studied using different carriers. Among water, surfactant solution, and surfactant foam, the nZVI transport and carrying abilities fo...
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The delivery of nano-zerovalent iron (nZVI) as a remediation agent to targeted areas in soil was studied using different carriers. Among water, surfactant solution, and surfactant foam, the nZVI transport and carrying abilities followed the order of surfactant foam > surfactant solution > water. The nZVI migration was also facilitated by increased soil particle size and high surfactant concentration. Batch experiments probed the remediation of dichlorodiphenyltrichloroethane (DDT)-contaminated sand under different conditions. Compared to surfactant solution, the use of foam as a carrier achieved much higher DDT removal efficiencies for both coarse (foam/solution: 99/69%) and fine (foam/solution: 60/26%) sands. Additionally, the DDT removal efficiency was strongly influenced by surfactant concentration: foams generated using 1 and 5 g L−1sodium lauryl ether sulfate (SLES) solutions reached the respective efficiencies of 44% and 75% under identical experimental conditions. However, the nature of the surfactant did not significantly affect the total removal efficiency of DDT. Solubilization, increased sweep efficiency, and reduction by nZVI were identified as factors affecting the DDT removal efficiency, and all three of them were involved when foam-nZVI was used as the flushing fluid.
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摘要 :
Bacterial response to surface topography during biofilm formation was studied using 5 μm tall line patterns of poly (dimethylsiloxane) (PDMS). Escherichia coli cells attached on top of protruding line patterns were found to align...
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Bacterial response to surface topography during biofilm formation was studied using 5 μm tall line patterns of poly (dimethylsiloxane) (PDMS). Escherichia coli cells attached on top of protruding line patterns were found to align more perpendicularly to the orientation of line patterns when the pattern narrowed. Consistently, cell cluster formation per unit area on 5?μm wide line patterns was reduced by 14-fold compared to flat PDMS. Contrasting the reduced colony formation, cells attached on narrow patterns were longer and had higher transcriptional activities, suggesting that such unfavorable topography may present a stress to attached cells. Results of mutant studies indicate that flagellar motility is involved in the observed preference in cell orientation on narrow patterns, which was corroborated by the changes in cell rotation pattern before settling on different surface topographies. These findings led to a set of new design principles for creating antifouling topographies, which was validated using 10?μm tall hexagonal patterns.
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